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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
08/11/2017 |
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Data da última atualização: |
23/09/2019 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
MONTEIRO, J. P.; SANTOS, J. M. L. dos; VASCONCELOS, J. F.; FROTA, G. A.; ANDRÉ, W. P. P.; RIBEIRO, W. L. C.; MELO, A. C. F. L.; TEIXEIRA, M.; VIEIRA, L. da S.; BEVILAQUA, C. M. L. |
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Afiliação: |
JOMAR PATRICIO MONTEIRO, CNPC; Jessica Maria Leite dos Santos, Universidade Estadual do Ceará (UECe) - Fortaleza, CE, Brazil; Janaelia Ferreira Vasconcelos, Universidade Estadual do Vale do Acaraú (UVA) -Sobral, CE, Brazil; Gracielle Araújo Frota; Weibson Paz Pinheiro Andre, UECe - Fortaleza, CE, Brazil; Wesley Lyeverton Correia Ribeiro, UECe - Fortaleza, CE, Brazil; Ana Carolina Fonseca Lindoso Melo; MARCEL TEIXEIRA, CNPC; LUIZ DA SILVA VIEIRA, CNPC; Claudia Maria Leal Bevilaqua, UECe - Fortaleza, CE, Brazil. |
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Título: |
Molecular development of oxfendazole resistance starting with a susceptible Haemonchus contortus isolate. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
In: INTERNATIONAL CONFERENCE OF THE WORLD ASSOCIATION FOR THE ADVANCEMENT OF VETERINARY PARASITOLOGY, 26., 2017, Kuala Lumpur, Malaysia. Abstract book. Perth: WAAVP, 2017.p. 516. Abstract 4588. |
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Idioma: |
Inglês |
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Notas: |
In conjunction with 53rd MSPTM Annual Conference. |
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Conteúdo: |
Abstract: Haemonchus contortus is one of the main small ruminant parasites in tropical areas and its control is traditionally done through the utilization of synthetic anthelmintics such as benzimidazoles (BZ). BZ resistance is associated to single nucleotide polymorphisms (SNP) located in the Beta-tubulin isotype 1 gene: F200Y, F167Y and E198A. Here we describe the rise of resistant mutations within a completely susceptible isolate (Inbred-susceptible-Edinburgh - ISE) in an experimental infection model in 3 sheep treated with increasing oxfendazole doses. After initial infection and rise in fecal egg counts, the drug regimen started with subdoses as low as 30% of the recommended dosage and were gradually increased to 100% over the course of a year. Experimental animals were infected every 1.5 months with 5,000 L3 larvae cultured from feces collected one week after each treatment. After an initial period when resistance was only detected in the F200Y locus, both resistant polymorphisms (F200Y and F167Y) were detected in increasing frequencies after each treatment. Eventually resistance at F200Y stationed at frequencies around 70% and decreased while resistance frequencies at F167Y kept rising and finally stationed at around 75%. Resistance at E198A was never detected in the studied period. Our study provide insights into the speed as to which each polymorphism may rise as BZ dosage increases converting a susceptible parasite population into a highly resistant one within a short time period. MenosAbstract: Haemonchus contortus is one of the main small ruminant parasites in tropical areas and its control is traditionally done through the utilization of synthetic anthelmintics such as benzimidazoles (BZ). BZ resistance is associated to single nucleotide polymorphisms (SNP) located in the Beta-tubulin isotype 1 gene: F200Y, F167Y and E198A. Here we describe the rise of resistant mutations within a completely susceptible isolate (Inbred-susceptible-Edinburgh - ISE) in an experimental infection model in 3 sheep treated with increasing oxfendazole doses. After initial infection and rise in fecal egg counts, the drug regimen started with subdoses as low as 30% of the recommended dosage and were gradually increased to 100% over the course of a year. Experimental animals were infected every 1.5 months with 5,000 L3 larvae cultured from feces collected one week after each treatment. After an initial period when resistance was only detected in the F200Y locus, both resistant polymorphisms (F200Y and F167Y) were detected in increasing frequencies after each treatment. Eventually resistance at F200Y stationed at frequencies around 70% and decreased while resistance frequencies at F167Y kept rising and finally stationed at around 75%. Resistance at E198A was never detected in the studied period. Our study provide insights into the speed as to which each polymorphism may rise as BZ dosage increases converting a susceptible parasite population into a highly resistant one within a sh... Mostrar Tudo |
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Palavras-Chave: |
Beta tubulin; Dosage effects; Resistance to anthelmintics; SNP. |
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Thesagro: |
Anti-Helmíntico; Haemonchus contortus; Resistência química. |
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Thesaurus Nal: |
Anthelmintics; Drug resistance; Oxfendazole. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/166452/1/CNPC-2017-Molecular.pdf
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Marc: |
LEADER 02735nam a2200349 a 4500
001 2079254
005 2019-09-23
008 2017 bl uuuu u00u1 u #d
100 1 $aMONTEIRO, J. P.
245 $aMolecular development of oxfendazole resistance starting with a susceptible Haemonchus contortus isolate.$h[electronic resource]
260 $aIn: INTERNATIONAL CONFERENCE OF THE WORLD ASSOCIATION FOR THE ADVANCEMENT OF VETERINARY PARASITOLOGY, 26., 2017, Kuala Lumpur, Malaysia. Abstract book. Perth: WAAVP, 2017.p. 516. Abstract 4588.$c4588
500 $aIn conjunction with 53rd MSPTM Annual Conference.
520 $aAbstract: Haemonchus contortus is one of the main small ruminant parasites in tropical areas and its control is traditionally done through the utilization of synthetic anthelmintics such as benzimidazoles (BZ). BZ resistance is associated to single nucleotide polymorphisms (SNP) located in the Beta-tubulin isotype 1 gene: F200Y, F167Y and E198A. Here we describe the rise of resistant mutations within a completely susceptible isolate (Inbred-susceptible-Edinburgh - ISE) in an experimental infection model in 3 sheep treated with increasing oxfendazole doses. After initial infection and rise in fecal egg counts, the drug regimen started with subdoses as low as 30% of the recommended dosage and were gradually increased to 100% over the course of a year. Experimental animals were infected every 1.5 months with 5,000 L3 larvae cultured from feces collected one week after each treatment. After an initial period when resistance was only detected in the F200Y locus, both resistant polymorphisms (F200Y and F167Y) were detected in increasing frequencies after each treatment. Eventually resistance at F200Y stationed at frequencies around 70% and decreased while resistance frequencies at F167Y kept rising and finally stationed at around 75%. Resistance at E198A was never detected in the studied period. Our study provide insights into the speed as to which each polymorphism may rise as BZ dosage increases converting a susceptible parasite population into a highly resistant one within a short time period.
650 $aAnthelmintics
650 $aDrug resistance
650 $aOxfendazole
650 $aAnti-Helmíntico
650 $aHaemonchus contortus
650 $aResistência química
653 $aBeta tubulin
653 $aDosage effects
653 $aResistance to anthelmintics
653 $aSNP
700 1 $aSANTOS, J. M. L. dos
700 1 $aVASCONCELOS, J. F.
700 1 $aFROTA, G. A.
700 1 $aANDRÉ, W. P. P.
700 1 $aRIBEIRO, W. L. C.
700 1 $aMELO, A. C. F. L.
700 1 $aTEIXEIRA, M.
700 1 $aVIEIRA, L. da S.
700 1 $aBEVILAQUA, C. M. L.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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| Registros recuperados : 14 | |
| 1. |  | CAVALCANTE, G. S.; RIBEIRO, W. L. C.; ANDRÉ, W. P. P.; ARAUJO FILHO, J. V.; MUNIZ, C. R.; BEVILAQUA, C. M. L.; MORAIS, S. M. Alterações ultraestruturais em Haemonchus contortus expostos ao látex de Calotropis procera. In: CONGRESSO BRASILEIRO DE PARASITOLOGIA VETERINÁRIA, 20., 2018, Londrina, PR. Anais... Londrina, PR: CBPV; UEL, 2018. p.285. 17 a 19 de setembro de 2018.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 2. | | SANTOS, J. M. L. dos; MONTEIRO, J. P.; RIBEIRO, W. L. C.; MACEDO, I. T. F.; ARAÚJO FILHO, J. V. de; ANDRE, W. P. P. High levels of benzimidazole resistance and beta-tubulin isotype 1 SNP F167Y in Haemonchus contortus populations from Ceará State, Brazil. Small Ruminant Research, Amsterdam v. 146, p. 48-52, Jan. 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
|  |
| 3. | | SANTOS, J. M. L. dos; RIBEIRO, W. L. C.; ANDRÉ, W. P. P.; ARAÚJO FILHO, J. V. de; MACEDO, I. T. F.; VASCONCELOS, A. L. C. F.; MONTEIRO, J. P.; VIEIRA, L. da S.; BEVIAQUA, C. M. L. Avaliação do controle de nematoides gastrintestinais em propriedades de ovinos no estado do Ceará. In: CONGRESSO BRASILEIRO DE PARASITOLOGIA VETERINÁRIA, 18., 2014, Gramado. Fronteiras da parasitologia: anais. Gramado: Colégio Brasileiro de Parasitologia Veterinária, 2014.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 4. | | SANTOS, J. M. L. dos; MACEDO, I. T. F.; SOUSA, M. M. de; RIBEIRO, W. L. C.; SILVA JÚNIOR, J. B. e.; CARVALHO, J. R.; VIEIRA, L. da S.; BEVILAQUA, C. M. L.; SIMÕES-MATTOS, L. Resistência a benzimidazóis em nematóides gastrintestinais de caprinos mantidos em condições experimentais em Sobral, Ceará. In: CONGRESSO BRASILEIRO DE PARASITOLOGIA VETERINÁRIA, 17., 2012, São Luis. Parasitologia veterinária, bem estar e produção animal: anais. São Luis: Colégio Brasileiro de Parasitologia Veterinária, 2012. p. 115. Resumo PH092.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 5. | | MONTEIRO, J. P.; SANTOS, J. M. L. dos; VASCONCELOS, J. F.; FROTA, G. A.; ANDRÉ, W. P. P.; RIBEIRO, W. L. C.; MELO, A. C. F. L.; TEIXEIRA, M.; VIEIRA, L. da S.; BEVILAQUA, C. M. L. Molecular development of oxfendazole resistance starting with a susceptible Haemonchus contortus isolate. In: INTERNATIONAL CONFERENCE OF THE WORLD ASSOCIATION FOR THE ADVANCEMENT OF VETERINARY PARASITOLOGY, 26., 2017, Kuala Lumpur, Malaysia. Abstract book. Perth: WAAVP, 2017.p. 516. Abstract 4588. In conjunction with 53rd MSPTM Annual Conference.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 6. | | MONTEIRO, J. P.; SANTOS, J. M. L. dos; ANDRÉ, W. P. P.; VASCONCELOS, J. F.; FROTA, G. A.; RIBEIRO, W. L. C.; FREITAS, E. P. de; MACEDO, I. T. F.; TEIXEIRA, M.; VIEIRA, L. da S.; BEVILAQUA, C. M. L. Molecular diagnostic for levamisol resistance in Haemonchus contortus. In: INTERNATIONAL CONFERENCE OF THE WORLD ASSOCIATION FOR THE ADVANCEMENT OF VETERINARY PARASITOLOGY, 26., 2017, Kuala Lumpur, Malaysia. Abstract book. Perth: WAAVP, 2017. p. 381. Abstract 4592. In conjunction with 53rd MSPTM Annual Conference.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 7. | | SANTOS, J. M. L. dos; MONTEIRO, J. P.; RIBEIRO, W. L. C.; MACEDO, I. T. F.; CAMURÇA-VASCONCELOS, A. L. F.; VIEIRA, L. da S.; BEVILÁQUA, C. M. L. Identification and quantification of benzimidazole resistance polymorphisms in Haemonchus contortus isolated in Northeastern Brazil. Veterinary Parasitology, v. 199, n. 3/4, p. 160-164, Jan. 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 8. | | SANTOS, J. M. L. dos; VASCONCELOS, J. F.; FROTA, G. A.; RIBEIRO, W. L. C.; ANDDRÉ, W. P. P.; VIEIRA, L. da S.; TEIXEIRA, M.; BEVILAQUA, C. M. L.; MONTEIRO, J. P. Haemonchus contortus Beta-tubulin isotype 1 gene F200Y and F167Y SNPs are both selected by ivermectin and oxfendazole treatments with differing impacts on anthelmintic resistance. Veterinary Parasitology, v. 248, p. 90-95, Dec. 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 9. | | SANTOS, J. M. L. dos; FREITAS, E. P. de; ARAÚJO FILHO, J. V. de; MONTEIRO, P. R.; RIBEIRO, W. L. C.; ANDRE, W. P. P.; VIEIRA, L. da S.; MONTEIRO, J. P.; BEVILAQUA, C. M. L. Frequência de polimorfismos responsáveis pela resistência a benzimidazóis em populações de Haemonchus contortus do Ceará. In: SIMPÓSIO INTERNACIONAL DE RAÇAS NATIVAS: SUSTENTABILIDADE E PROPRIEDADE INTELECTUAL, 1., 2015, Teresina. Anais... Teresina: SFA-PI: ABCPD, 2015. p. 649. Ref.: P-378.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 10. | | RIBEIRO, W. L. C.; CAMURÇA-VASCONCELOS, A. L. F.; SANTOS, J. M. L. dos; MACEDO, I. T. F.; RIBEIRO, J. de C.; OLIVEIRA, E. F. de; PAULA, H. C. B. de; BEVILAQUA, C. J. L. The use of Eucalyptus staigeriana nanoemulsion for control of sheep haemonchosis. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 3, p. 221-226, março 2017. Título em português: Uso da nanoemulsão de Eucalyptus staigeriana no controle da hemoncose em ovinos.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 11. | | ANDRÉ, W. P. P.; PAIVA JUNIOR, J. R. de; CAVALCANTE, G. S.; RIBEIRO, W. L. C.; ARAÚJO FILHO, J. V. de; SANTOS, J. M. L. dos; ALVES, A. P. N. N.; MONTEIRO, J. P.; MORAIS, S. M. de; SILVA, I. N. G. da; OLIVEIRA, L. M. B. de; ABREU, F. O. M. da S.; BEVILAQUA, C. M. L. Anthelmintic activity of nanoencapsulated carvacryl acetate against gastrointestinal nematodes of sheep and its toxicity in rodents. Brazilian Journal of Veterinary Parasitololgy, v. 29, n. 1, e013119, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 12. | | CAVALCANTE, G. S.; MORAIS, S. M. de; ANDRÉ, W. P. P.; ARAÚJO FILHO, J. V. de; MUNIZ, C. R.; ROCHA, L. O. da; RIBEIRO, W. L. C.; RODRIGUES, A. L. M.; OLIVEIRA, L. M. B. de; BEVILAQUA, C. M. L.; RAMOS, M. V. Chemical constituents of calotropis procera latex and ultrastructural effects on haemonchus contortus. Revista Brasileira de Parasitologia Veterinaria, v. 29, n. 2, article number e001320, p. 1-12, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 13. | | SANTOS, J. M. L. dos; MONTEIRO, J. P.; RIBEIRO, W. L. C.; MACEDO, I. T. F.; FONTENELE, J. A.; FREITAS, E.; RIBEIRO, J. de C.; SAMPAIO, R. A.; ARAÚJO FILHO, V.; CAMURÇA-VASCONCELOS, A. L. F.; VIEIRA, L. da S.; BEVILÁQUA, C. M. L. Identification and quantification of polymorphisms responsible for the resistance to benzimidazoles in Haemonchus contortus isolated in the State of Ceara, Northeastern of Brazil. In: INTERNATIONAL CONFERENCE OF THE WORLD ASSOCIATION FOR THE ADVANCEMENT OF VETERINARY PARASITOLOGY, 24., 2013, Perth. [Electonic abstracts]... Perth: WAAVP, 2013. Poster 125. p. 518.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 14. | | BARBOSA, M. L. F.; RIBEIRO, W. L. C.; ARAÚJO FILHO, J. V. de; PEREIRA, R. de C. A.; ANDRÉ, W. P. P.; MELO, A. C. F. L.; CASTELO BRANCO, D. de S. C. M.; BENEVIDES, S. D.; OLIVEIRA, L. M. B. de; BEVILAQUA, C. M. L. In vitro anthelmintic activity of Lippia alba essential oil chemotypes against Haemonchus contortus. Experimental Parasitology, v. 244, art. 108439, 7 p., Jan. 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 4 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| Registros recuperados : 14 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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